Trends in microbiology. The host range of a bacteriophage is the taxonomic diversity of hosts it can successfully infect. Host range, one of the central traits to understand in phages, is determined by a range of molecular … Expand. The genera of bacteriophages and their receptors are the major determinants of host range. Environmental microbiology. The host range of phages is a key to understand their impact on bacterial ecology and evolution. Because of the complexity of phage-host interactions, the variables that determine the breadth of a … Expand.
The War between Bacteria and Bacteriophages. View 2 excerpts, cites background and methods. Diversity of phage infection types and associated terminology: the problem with 'Lytic or lysogenic'.
FEMS microbiology letters. Phage therapy. Phage Ecology and Bacterial Pathogenesis. Ecology of Viruses Infecting Bacteria. Phage choice, isolation, and preparation for phage therapy. Current pharmaceutical biotechnology. Designing phage therapeutics. Initially, we address how phage host range can and should be defined plus summarize claims of host ranges spanning multiple bacterial genera.
Subsequently, we review bacterial mechanisms of phage resistance. These include adsorption resistance, which results in reduced interaction between phage and bacterium; what we describe as "restriction," where bacteria live but phages die; and abortive infections, where both phage and bacterium die. Adsorption resistance includes loss of phage receptor molecules on hosts as well as physical barriers hiding receptor molecules e.
Restriction mechanisms include phage-genome uptake blocks, superinfection immunity, restriction modification, and CRISPR, all of which function postphage adsorption but prior to terminal phage takeover of host metabolism.
Standard laboratory selection methods, involving exposure of planktonic bacteria to high phage densities, tend to directly select for these prehost-takeover resistance mechanisms. Alternatively, resistance mechanisms that do not prevent bacterium death are less readily artificially selected. Contrasting especially bacteria mutation to adsorption resistance, these latter mechanisms likely are an underappreciated avenue of bacterial resistance to phage attack.
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Friends or Foes? Multi-species host range of staphylococcal phages isolated from wastewater. Active virus-host interactions at sub-freezing temperatures in Arctic peat soil. Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.
Rule-based simulation of temperate bacteriophage infection: restriction-modification as a limiter to infection in bacterial populations. Phage host range and efficiency of plating. Preventing biofilms of clinically relevant organisms using bacteriophage. The role of interactions between phage and bacterial proteins within the infected cell: a diverse and puzzling interactome.
Revenge of the phages: defeating bacterial defences. Host receptors for bacteriophage adsorption. Joining Europe PMC. Tools Tools overview. ORCID article claiming. Journal list. Contrasting especially bacteria mutation to adsorption resistance, these latter mechanisms likely are an underappreciated avenue of bacterial resistance to phage attack.
Abstract Host range describes the breadth of organisms a parasite is capable of infecting, with limits on host range stemming from parasite, host, or environmental characteristics.
Publication types Review. Substances Receptors, Virus.
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